【题目(Title)】 Sexual functioning in chronically depressed patients treated with SSRI antidepressants: a pilot study.

【著者(Authors)】 Piazza LA,  Markowitz JC,  Kocsis JH,  Leon AC,  Portera L,  Miller NL,  Adler D
【来源(Source)】 American Journal of Psychiatry [NLM - MEDLINE]. Dec 1997. Vol. 154, Iss. 12; pg. 1757
【关键词(Keywords)】 .

【摘要(Abstract)】：
OBJECTIVE: This prospective study assessed changes in depression and sexual functioning in chronically depressed men and women during treatment with selective serotonin reuptake inhibitors (SSRIs). METHOD: Twenty-five subjects (14 women, 11 men) with DSM-III-R dysthymia, chronic major depression, or double depression were administered the Arizona Sexual Experience Scale and the Hamilton Depression Rating Scale before and after 6 weeks of treatment with sertraline or paroxetine. RESULTS: As measured by scores on the Arizona Sexual Experience Scale, desire, psychological arousal, and overall sexual functioning significantly improved in women; orgasm delay, orgasm satisfaction, and overall sexual functioning significantly worsened in men. CONCLUSIONS: This study suggests that after SSRI treatment, difficulties with desire and psychological arousal in depressed women tend to remit, whereas in men orgasmic dysfunction appears to be a side effect to medication.